LumiJet is a closed-loop embodied-AI platform that makes vitiligo care more selective and less invasive. At each session, LumiJet transforms optical, photoacoustic, impedance, and prior-response data into a patient-specific longitudinal 3D pigment map, distinguishing regions requiring intervention from those improving or requiring remeasurement. Rather than applying uniform point-by-point treatment, a physics-informed AI model predicts how needle-free NanoJet delivery and light-triggered plasmonic release interact beneath the skin, then an AI planner creates a minimum-effective protocol. The protocol pairs each selected site with NanoJet settings and matched localized surface plasmon resonance (LSPR) conditions while limiting non-lesional exposure. A calibrated sensing–delivery coordinate system and real-time skin-landmark tracking translate the plan into guided device action. Independent safety controls gate execution, while on-device AI keeps raw skin data local. At later sessions, LumiJet compares the updated map with prior response and redirects intervention toward persistent regions, making care more selective as the skin changes.